A drug already used to treat parasitic infections, and once looked at for cancer, also attacks the human immunodeficiency virus (HIV) in a new and powerful way, according to new research.
Past research has established that HIV has "learned" to hide out in certain human cells where it is safe from the body's counterattack, cells that come to serve as viral reservoirs. Operating from these havens, the virus slowly builds its numbers over more than a decade until it finally becomes capable of dismantling human immune defenses. In the end stages, this process leaves patients vulnerable to the opportunistic infections of AIDS. The newly published work explains for the first time how the virus makes chemical changes that keep its chosen reservoirs alive long past their normal lifespan. The new study also provides the first evidence that an existing ant-parasite drug can reverse this deadly longevity.
These results are profound because, in discovering exactly how HIV hides in the body, this could help us take away its hiding places.
*This research was published online in the open access journal Retrovirology January 30, 2008.
Adapted from materials provided by University of Rochester Medical Center.
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